Formulation and Evaluation of Proliposomal Gel Containing Repaglinide Using Mannitol as Water Soluble Carrier

Aim: The aim of the present investigation was to design a proliposomal gel system of Repaglinide for the treatment of type 2 diabetes mellitus that is capable of delivering entrapped drug over an extended period of time. Method: Proliposomes of Repaglinide were prepared by thin film hydration technique by varying the composition mannitol, soya lecithin and cholesterol. Proliposome formulations were characterized for compatibility, vesicle size, drug content, entrapment efficiency, surface morphology, zeta potential, DSC investigation, invitro drug release and stability studies. The proliposomal gel was prepared for optimized proliposomal formulation F4 by incorporated into 1% carbopol gel. The in-vivo skin irritation study and hypoglycemic activity was carried out for the gel F4-G1. Results: Drug and physical mixture were characterized by FTIR, the result of IR and study showed that no interaction between drug and polymers and other formulation parameters of formulated proliposomes and proliposomal gel are evaluated which showed better results. Conclusion: Proliposomal gel F4-G1 was proved nonirritant and shows better stability, more hypoglycemic effect as compared to oral formulation because it provide reduction in glucose level with controlled manner upto 24 hrs. Hence, proliposomes drug delivery system was better choice for controlled release of drug through topical drug delivery.